Histological and Functional Effect of Aluminium on Male Reproductive System

Various findings are given emphasis to Aluminium which has more and more obvious disturbance of the reproductive processes other body organs. The purpose of this review is to give a comprehensive report of the existing data on Aluminium induced male reproductive toxicity in different animal models. Along with, we also have made an attempt to present the possible mechanism related to Aluminium induced reproductive toxicity suggested by various researchers. The findings showed that Aluminium is one of the ubiquitous metals and is being immensely used in industries, pharmaceuticals, food additives and consumer products. Alongside, there has been an increased incidence of exposure to the general population which can cause serious effect on various systems of the body including male reproductive system. The present analysis indicates that increase oxidative stress, alteration in spermatogenesis as well as membrane function, disruption in cell signaling and the impairment of blood testis barrier, affect the endocrine system which might be the various possible mechanisms of Al induced male reproductive toxicity.